Biomarkers for pre-selection of patients for anti-igf1r therapy

Details Biomarkers for pre-selection of patients for anti-igf1r therapy Biomarkers for pre-selection of patients for anti-igf1r therapy

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 31/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2589885

The present invention provides methods for identifying patients whose cancers are likely to be responsive to IGF1R inhibitory anti-cancer therapy along with methods for treating such patients. Patients identified by a method of the present application can be treated with any of several known IGF1R inhibitory agents including antibodies, small molecule inhibitors and anti-sense nucleic acids.

La présente invention a trait à des procédés pour l'identification de patients dont les cancers sont susceptibles d'être sensibles à une thérapie anticancéreuse inhibitrice du récepteur du facteur de croissance semblable à l'insuline 1 ainsi qu'à des procédés pour le traitement de tels patients. Des patients identifiés par le procédé de la présente invention peuvent être traités avec un quelconque parmi les agents connus inhibiteurs du récepteur du facteur de croissance semblable à l'insuline, des inhibiteurs à petites molécules et des acides nucléiques antisens.

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