Biomarkers for predicting anti-tnf responsiveness or...

C - Chemistry – Metallurgy – 40 – B

Patent

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Details

C40B 40/06 (2006.01) A61K 45/00 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) G01N 33/48 (2006.01)

Patent

CA 2690898

The present disclosure provides biomarkers that are predictive a subject's responsiveness or non-responsiveness to an anti-TNF therapy. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities (e.g., an anti-TNF therapy or a non-anti-TNF therapy) for a subject suffering from a disease such as an immune disorder.

La présente invention concerne des biomarqueurs prédictifs d'une réactivité ou non-réactivité d'un sujet à une thérapie anti-TNF. Les biomarqueurs, compositions et procédés décrits ici sont utiles dans la sélection de modalités de traitement appropriées (par exemple, une thérapie anti-TNF ou une thérapie non-anti-TNF) pour un sujet souffrant d'une maladie telle qu'un trouble immunitaire.

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