Biomarkers for prenatal diagnosis of congenital cytomegalovirus

Details Biomarkers for prenatal diagnosis of congenital cytomegalovirus Biomarkers for prenatal diagnosis of congenital cytomegalovirus

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2703165

The invention provides compositions and methods useful for early detection of congenital CMV infection, predicting the likelihood and severity of congenital CMV disease, and monitoring the efficacy of therapeutic approaches. Compositions of the present invention include biomarkers that are differentially expressed in CMV- infected mothers and fetuses compared to uninfected individuals.

L'invention propose des compositions et des procédés utiles pour une détection précoce d'infections à CMV congénital, prévoyant la probabilité et l'importance d'un CMV congénital et surveillant l'efficacité des approches thérapeutiques. Des compositions de l'invention comprennent des biomarqueurs qui sont exprimés différemment chez des mères et des ftus affectés par le CMV, par comparaison à des individus non affectés.

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