Biomarkers for the efficacy of calcitonin and parathyroid...

A - Human Necessities – 61 – K

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A61K 38/23 (2006.01) A61K 38/29 (2006.01) A61P 19/08 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2546111

A mufti-organ gene profiling analysis of the results of an administration to a subject of salmon calcitonin or a parathyroid hormone analogue provides biomarkers of calcitonin treatment efficacy and parathyroid hormone or parathyroid hormone analogue treatment efficacy. Among the biomarkers are the expression profiles of the genes for Y-box binding protein, BMPs, FGFs, IGFs, VEGF, .alpha.-2-HS glycoprotein (AHSG), OSF, nuclear receptors (steroid/thyroid family) and others. The results obtained support the anabolic effect of salmon calcitonin on bone metabolism.

Selon l'invention, une analyse par profilage génétique multiorganique des résultats d'une administration à un sujet de calcitonine de saumon ou d'un analogue de parathormone permet d'obtenir des biomarqueurs de l'efficacité d'un traitement à la calcitonine et de l'efficacité d'un traitement avec un analogue de parathormone. Parmi les biomarqueurs figurent les profils d'expression des gènes pour la protéine de liaison à la boîte Y, soit les BMP, les FGF, les IGF, le VEGF, la glycoprotéine .alpha.-2-HS (AHSG), l'OSF, les récepteurs nucléaires (famille des stéroïdes/thyroïdes) et analogues. Les résultats obtenus soutiennent l'effet anabolisant de la calcitonine de saumon sur le métabolisme osseux.

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