G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/573 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2658895
A method for quantifying a neurodegenerative disorder in a patient that includes obtaining a fluid sample from the subject; measuring a protein biomarker complex in said fluid sample and correlating the measurement with mild cognitive impairment or Alzheimer's disease status. The biomarkers include those that comprise at least one of a transthyretin protein and/or a prostaglandin-H2 D-isomerase protein, and at least one second, different protein selected from a transthyretin, prostaglandin-H2 D-isomerase, beta-2-microglobulin, cystatin C, superoxide dismutase [Cu-Zn], plasma retinol-binding protein, phosphatidylethanolamine-binding protein, carbonic anhydrase 2, prostaglandin-H2 D-isomerase, and/or serotransferrin protein.
L'invention porte sur une méthode de quantification d'un trouble neurodégénératif chez un patient consistant: à prélever un échantillon de fluide du patient; à mesurer un complexe de biomarqueurs de protéine présent dans l'échantillon; et à corréler la mesure avec un léger trouble cognitif ou la maladie d' D'ALZHEIMER. Les biomarqueurs sont de ceux qui contiennent: au moins une protéine du type transthyrétine et/ou prostaglandine-H2 D-isomérase, et au moins une deuxième protéine différente sélectionnée parmi des protéines des types: transthyrétine, prostaglandine-H2 D-isomérase, bêta-2-microglobuline, cystatine C, superoxyde dismutase [Cu-Zn], de fixation du rétinol plasmique, de fixation de la phosphatidyléthanolamine, carbonique anhydrase 2, prostaglandine-H2 D-isomérase, et/ou sérotransferrine.
Lovell Mark A.
Lynn Bert C.
Gowling Lafleur Henderson Llp
University Of Kentucky Research Foundation
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