Biomarkers of sirtuin activity and methods of use thereof

Details Biomarkers of sirtuin activity and methods of use thereof Biomarkers of sirtuin activity and methods of use thereof

C - Chemistry, Metallurgy

12

Q

C12Q 1/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2680823

Provided are methods for monitoring sirtuin modulation in a subject, for example, during therapeutic treatment with a sirtuin modulating compound. The methods involve determining the expression level of one or more sirtuin biomarkers in a biological sample from the subject. Also provided are methods for identifying compounds that modulate the activity of a sirtuin protein using one or more sirtuin biomarkers.

La présente invention concerne des procédés pour suivre la modulation de la sirtuine chez un sujet, par exemple, pendant un traitement thérapeutique avec un composé modulateur de sirtuine. Les procédés comprennent la détermination du taux d'expression d'un ou plusieurs biomarqueurs de la sirtuine dans un échantillon biologique prélevé sur un sujet. La présente invention concerne également des procédés pour identifier des composés qui modulent l'activité de la protéine sirtuine en utilisant un ou plusieurs biomarqueurs de la sirtuine.

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