Biomaterial

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/56 (2006.01) A61L 27/46 (2006.01) A61L 27/48 (2006.01)

Patent

CA 2659385

A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.

L'invention concerne un procédé pour la préparation d'un biomatériau composite consistant à : produire un premier composant pratiquement solide comprenant un ou plusieurs composants parmi le collagène, un glycosaminoglycane, l'albumine, le hyaluronane, le chitosane et des polypeptides synthétiques comprenant une partie de la séquence polypeptidique du collagène, et éventuellement une matière inorganique, ledit composant ayant au moins une partie de sa surface qui est poreuse ; produire une composition fluide comprenant un ou plusieurs composants parmi le collagène, un glycosaminoglycane, l'albumine, le hyaluronane, le chitosane et des polypeptides synthétiques comprenant une partie de la séquence polypeptidique du collagène, et un véhicule liquide et éventuellement une matière inorganique ; mettre en contact ladite composition fluide avec ladite partie de surface poreuse dudit premier composant ; refroidir ladite composition fluide à une température à laquelle le véhicule liquide se transforme en une pluralité de particules ou cristaux solides ; enlever au moins une partie de la pluralité des particules ou cristaux solides par sublimation et/ou évaporation.

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