A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/54 (2006.01) A61K 47/40 (2006.01) A61K 47/48 (2006.01) A61L 27/34 (2006.01) A61L 27/56 (2006.01) A61L 29/08 (2006.01) A61L 29/14 (2006.01) A61L 29/16 (2006.01) A61L 31/10 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01) C08B 37/00 (2006.01)
Patent
CA 2587435
The invention relates to a method for preparing a biomaterial comprising at least one bioactive molecule from a base biomaterial. Said method is characterised by the following successive operations: a) a solid mixture of cyclodextrine(s) and/or cyclodextrine derivative(s) and/or cyclodextrine inclusion complex(es) and/or cyclodextrine derivatives, at least one poly(carboxylic) acid, and optionally a catalyst, is applied to the base biomaterial; and b) the base biomaterial and mixture are heated to a temperature of between 100 °C and 220 °C, for between 1 and 60 minutes; c) washed with water; and d) dried. The inventive method is also characterised in that at least one bioactive agent is incorporated into the biomaterial, by impregnating the biomaterial following the drying stage in a concentrated solution of a bioactive agent.
La présente invention a pour objet un procédé de préparation d'un biomatériau comportant au moins une molécule bioactive à partir d'un biomatériau de base caractérisé par les opérations successives suivantes effectuées sur ledit biomatériau de base: a) application d'un mélange solide de : cyclodextrine(s) et/ou de dérivé(s) de cyclodextrine(s) et/ou de complexe(s) d'inclusion de cyclodextrine(s) et/ou de dérivés de cyclodextrine(s), d'au moins un acide poly(carboxylique), et éventuellement d'un catalyseur; b) chauffage à une température comprise entre 1000C et 2200C, pendant une durée de 1 à 60 minutes ; c) lavage à l'eau; d) séchage, et en ce qu'au moins un agent bioactif est incorporé au biomatériau, par imprégnation du biomatériau après l'étape de séchage dans une solution concentrée d'agent bioactif.
Blanchemain Nicolas
Boschin Francois
Delcourt-Debruyne Elisabeth
Haulon Stephan
Hildebrand Hartmut Friedrich
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
L'universite de Droit Et Sante
L'universite de Droit Et Sante (lille 2)
Universite Des Sciences Et Technologies de Lille Saic
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