Biomaterials modified with superoxide dismutase mimics

Details Biomaterials modified with superoxide dismutase mimics Biomaterials modified with superoxide dismutase mimics

C - Chemistry, Metallurgy

07

F

C07F 13/00 (2006.01) A61L 27/54 (2006.01) C07F 15/02 (2006.01)

Patent

CA 2374472

The present invention relates to biomaterials modified with non-proteinaceous catalysts for the dismutation of superoxide, and processes for making such materials. This modification may be by covalent conjugation, copolymerization, or admixture of the non-proteinaceous catalysts with the biomaterial. The resulting modified biomaterials exhibit a marked decrease in inflammatory response and subsequent degradation when placed in contact with vertebrate biological systems.

L'invention porte sur des biomatériaux modifiés par des catalyseurs non protéiques assurant la dismutation de superoxydes, et sur leurs procédés d'obtention. Cette modification peut se faire par conjugaison covalente, par copolymérisation, ou par mélange des catalyseurs non protéiques aux biomatériaux. Les biomatériaux modifiés résultant présentent une nette décroissance de la réponse inflammatoire et de la dégradation s'en suivant quand mis en contact avec des système biologiques de vertébrés.

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