C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01) A61L 27/00 (2006.01) A61L 27/24 (2006.01) A61L 27/38 (2006.01) A61L 27/54 (2006.01) C12N 5/00 (2006.01) C12N 11/00 (2006.01)
Patent
CA 2723760
This invention relates to biomimetic implants containing mammalian cells which are induced by their environment to produce gradients of diffusible factors. This may be useful in eliciting a physiological pro-angiogenic response which stimulates angiogenesis and revascularisation in tissue adjacent the implant, for example in therapeutic applications in which increased angiogenesis and/or vasculogenesis is required. This may also be useful in providing biomimetic mammalian cell niches for cell culture and differentiation.
L'invention concerne des implants biomimétiques contenant des cellules mammaliennes qui sont induites par leur environnement pour produire des gradients de facteurs diffusibles. Ceci peut être utile pour provoquer une réponse physiologique pro-angiogénique qui stimule l'angiogenèse et la revascularisation dans le tissu adjacent à l'implant, par exemple dans des applications thérapeutiques pour lesquelles une augmentation de l'angiogenèse et/ou de la vasculogenèse est requise. Ceci peut également être utile pour fournir des niches de cellules mammaliennes biomimétiques pour la culture et la différenciation cellulaire.
Brown Robert
Cheema Umber
Hadjipanayi Ektoras
Macrobert Sandy
Ridout & Maybee Llp
Ucl Business Plc
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