Biomimetic prosthetic ligament and production method thereof

Details Biomimetic prosthetic ligament and production method thereof Biomimetic prosthetic ligament and production method thereof

A - Human Necessities

61

L

A61L 27/34 (2006.01) A61F 2/08 (2006.01) A61L 27/18 (2006.01) A61L 27/54 (2006.01)

Patent

CA 2513359

The invention relates to biomimetic artificial prostheses which are made from polyester, such as polyethylene terephthalate, and to a method for the biomimetic functionalization of said prostheses. The inventive method is characterized in that it comprises a step involving the grafting of biologically-active polymers or copolymers to the polyester surface of the aforementioned prostheses, said grafting step consisting of the peroxidation of the surface by means of ozonation followed by a step comprising the radical polymerization of a solution of at least one monomer. Said method also comprises an optional step consisting in impregnating the prostheses with type I and/or II collagen and/or fibronectins. The prostheses thus obtained enable a normal and uniform regrowth of the fibroblasts, thereby significantly improving the biological integration of such polyester prostheses.

La présente invention concerne des prothèses artificielles biomimétiques en polyester et notamment en polyéthylène téréphtalate ainsi que le procédé de fonctionnalisation biomimétique desdites prothèses. Ce procédé est remarquable en ce qu'il comporte une étape de greffage de polymères ou copolymères biologiquement actifs à la surface en polyester desdites prothèses, laquelle étape de greffage consiste à réaliser une peroxydation de la surface par ozonation suivie d'une étape de polymérisation radicalaire d'une solution d'au moins un monomère. Ce procédé comporte en outre une étape optionnelle d'imprégnation des prothèses par des fibronectines et/ou du collagène de type I et/ou II. Les prothèses obtenues selon l'invention permettent une repousse homogène et normale des fibroblastes, augmentant considérablement l'intégration biologique de telles prothèses en polyester.

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