Biomimetic scaffolds

Details Biomimetic scaffolds Biomimetic scaffolds

C - Chemistry, Metallurgy

08

L

C08L 71/02 (2006.01) A61K 31/765 (2006.01) A61P 9/00 (2006.01) A61P 17/02 (2006.01) A61P 25/00 (2006.01) C08L 67/04 (2006.01) C12N 5/00 (2006.01) C12N 11/08 (2006.01)

Patent

CA 2640601

The invention provides a composition comprising a nanofiber polymer in which the fibers of the nanofiber polymer are aligned, and a molecule is covalently attached, either directly or through a linker, to the nanofiber polymer. This molecule is capable of either covalently or non-covalently attaching to a member selected from an extracellular matrix component, a growth factor, and combinations thereof. The invention also provides methods of making the composition and methods of using the compositions to add new tissue to a subject, such as a human.

L'invention concerne une composition comprenant un polymère de nanofibres dans lequel les fibres du polymère de nanofibres sont alignées, et une molécule est attachée en covalence, soit directement soit au moyen d'un liant, au polymère de nanofibres. Cette molécule est capable de se fixer par covalence ou non à un élément sélectionné parmi un composant de matrice extracellulaire, un facteur de croissance, et des combinaisons de ceux-ci. L'invention propose aussi des procédés de fabrication de la composition et des procédés d'utilisation des compositions pour ajouter un nouveau tissu à un sujet, tel qu'un humain.

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