Biomolecule-linked biomimetic scaffolds

Details Biomolecule-linked biomimetic scaffolds Biomolecule-linked biomimetic scaffolds

C - Chemistry, Metallurgy

07

K

C07K 17/08 (2006.01) A61K 9/70 (2006.01) A61K 38/58 (2006.01) C07K 17/02 (2006.01) C08L 67/04 (2006.01) C08L 71/02 (2006.01) C08L 89/00 (2006.01) A61L 15/44 (2006.01) C07K 14/815 (2006.01) C12N 11/02 (2006.01) C12N 11/08 (2006.01) D01D 5/18 (2006.01)

Patent

CA 2654840

The invention provides a composition comprising a nanofiber polymer in which the fibers of the nanofiber polymer are aligned, and a molecule is covalently attached, either directly or through a linker, to the nanofiber polymer. This molecule is capable of either covalently or non-covalently attaching to a member selected from an extracellular matrix component, a growth factor, and combinations thereof. The invention also provides methods of making the composition and methods of using the compositions to add new tissue to a subject, such as a human.

L'invention concerne une composition comprenant un polymère de nanofibres, les fibres du polymère de nanofibres étant alignées et une molécule étant attachée de manière covalente, soit directement, soit par un groupe de liaison, au polymère de nanofibres. Cette molécule est capable de s'attacher de manière covalente ou non covalente à un élément choisi parmi un composant de matrice extracellulaire, un facteur de croissance et leurs combinaisons. L'invention concerne également des procédés de fabrication de la composition et des procédés d'utilisation des compositions pour ajouter de nouveaux tissus à un sujet, tel qu'un être humain.

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