C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61K 35/76 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) A61P 43/00 (2006.01) C12N 5/10 (2006.01) C12N 7/04 (2006.01) C12N 15/86 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2497313
It is intended to provide an efficient transduction method to the brain/central nerve system and a more efficient transduction method with the use of a virus envelope. Namely, a system for transferring a biomolecule into cells which contains: A) the biomolecule; B) a virus envelope; and C) glycosaminoglycan; and a method of transducing a biomolecule into the brain which involves the following steps: A) the step of transiently closing the cephalic or cervical artery; and B) the step of transferring the biomolecule into the brain while closing the cephalic or cervical artery.
L'invention vise à fournir un procédé de transduction efficace sur le système nerveux cérébral/central et un procédé de transduction plus efficace utilisant une enveloppe virale. L'invention concerne plus précisément un système de transfert d'une biomolécule dans des cellules contenant : (A) la biomolécule ; (B) une enveloppe virale ; et (C) un glycosaminoglycane ; ainsi qu'un procédé de transduction d'une biomolécule dans le cerveau faisant intervenir les étapes suivantes : (A) la fermeture transitoire de l'artère céphalique et cervicale ; et (B) le transfert de la biomolécule dans le cerveau ainsi que la fermeture de l'artère céphalique ou cervicale.
Kaneda Yasufumi
Morishita Ryuichi
Shimamura Munehisa
Anges Mg Inc.
Sim & Mcburney
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