Biomolecules having multiple attachment moieties for binding...

Details Biomolecules having multiple attachment moieties for binding... Biomolecules having multiple attachment moieties for binding...

C - Chemistry, Metallurgy

25

D

C25D 5/54 (2006.01) A61K 9/14 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) A61K 51/00 (2006.01) C07H 19/00 (2006.01) C07H 21/00 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/552 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2397091

Biomolecules are provided having multiple binding sites for attachment to a substrate surface. The multiple attachment sites may be produced directly on the biomolecule or through use of branched phosphoramidite moieties that can be added in multiple to form dendritic structures which can in turn provide attachment sites for substrate binding moieties. Substrate binding moieties may include noncovalent binding moieties. For covalent binding moieties oligonucleotides containing hydrazides are provided. These hydrazides can be introduced via protected building blocks such as phosphoramidites or via building blocks containing precursor forms of such hydrazides.

L'invention concerne des biomolécules possédant des sites de liaison multiples leur permettant de se fixer sur la surface d'un substrat. Ces sites de liaison multiples peuvent être produits directement sur la biomolécule ou peuvent être produits au moyen de fractions phosphoramidite ramifiées qui peuvent être ajoutées par unités multiples afin de former des structures dendritiques qui peuvent à leur tour fournir des sites de liaison permettant la fixation des fractions de liaison sur le substrat. Les fractions permettant la liaison avec le substrat peuvent comprendre des fractions de liaison non covalente ou covalente, les fractions de liaison covalente étant obtenues au moyen d'oligonucléotides contenant des hydrazides. Ces hydrazides peuvent être introduits par l'intermédiaire de motifs structuraux protégés tels que les phosphoramidites, ou de motifs structuraux contenant des précurseurs de ces hydrazides.

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