Biopolymer system for tissue sealing

Details Biopolymer system for tissue sealing Biopolymer system for tissue sealing

C - Chemistry, Metallurgy

08

J

C08J 3/075 (2006.01) A61L 15/22 (2006.01) A61L 17/00 (2006.01) A61L 24/04 (2006.01) C08B 37/08 (2006.01) C08L 5/08 (2006.01)

Patent

CA 2686132

A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises an alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide or both, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.

L'invention porte sur un réparateur de tissus et sur une procédure médicale permettant de réparer les tissus de mammifères vivants. Le réparateur comprend un hydrogel formé par gélification d'un prémélange disposé sur le tissu à réparer. Le prémélange comprend un chitosan alkylé ou une gélatine et un acide carboxylique polybasique et/ou un polysaccharide oxydé. Le prémélange peut également comprendre un réactif déshydratant et/ou un réactif d'activation au carbonyle. L'une des utilisations spécifiques du réparateur de tissus est la réparation de la dura mater après une chirurgie du cerveau pour empêcher une fuite du liquide cérébrospinal. Le réparateur de tissus peut en outre comporter un agent thérapeutique ou protecteur tel qu'un antibiotique ou un antiinflammatoire.

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