Bioprosthetic implants and method of making and using same

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/00 (2006.01) A61F 2/02 (2006.01) A61L 27/36 (2006.01) A61L 27/38 (2006.01)

Patent

CA 2196213

The invention provides bioprosthetic implants from which the lipids have been removed by treatment with enzymes which degrade lipids, and methods of making and using the same. The enzymes include lipases and phospholipases. The removal of lipids from the bioprosthetic implants according to the present invention decreases the calcification of the bioprosthesis. The bioprosthetic implants preferably may be recellularized with fibroblasts or myofibroblasts before implanting the bioprosthesis in the body of a person.

L'invention concerne des implants bioprothétiques dont les lipides ont été éliminés par traitement par des enzymes dégradant les lipides. L'invention a également pour objet des procédés de production et d'utilisation de ces implants. Ces enzymes comprennent des lipases et des phospholipases. L'élimination des lipides de ces implants selon la présente invention réduit la calcification de la bioprothèse. Ces implants bioprothétiques peuvent, de préférence, être recellularisés par des fibroblastes ou des myofibroblastes avant leur implantation dans le corps d'un patient.

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