Bioreductive compounds

Details Bioreductive compounds Bioreductive compounds

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2092616

ABSTRACT NOVEL BIOREDUCTIVE COMPOUNDS A quinoxaline or pyridopyrazine derivative of formula (I) Image (I) wherein R1 is a group containing a hydroxyl, oxiranyl, aziridine, alkylamino, pyrrolidino, morpholine, piperidino, piperazino, 2-nitroimidazolyl, or 5-nitrofuryl group; R2 is a hydrocarbyl, or heterocyclyl aromatic group unsubstituted or substituted by one or more substituents selected from halogen haloalkyl, alkyl, nitro, hydroxy, alkoxy and alkylenedioxy; The groups R3 are the same or different and each is hydrogen, alkyl, or hydroxy; X is -CH= or -N=, and X1 in hydrogen or halogon; and pharmaceutically acceptable salts thereof are useful in the treatment of tumours, and in particular hypoxic tumours. Processes for producing the compound and pharmaceutical compositions containing them.

Affiliated with

Also associated with

Rating

Bioreductive compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bioreductive compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioreductive compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2012789