Bioreductive cytotoxic agents

Details Bioreductive cytotoxic agents Bioreductive cytotoxic agents

C - Chemistry, Metallurgy

07

C

C07C 229/60 (2006.01) A61K 31/196 (2006.01) A61K 31/235 (2006.01) A61K 31/343 (2006.01) A61K 31/404 (2006.01) A61K 31/4184 (2006.01) A61K 31/5375 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07C 37/02 (2006.01) C07C 50/02 (2006.01) C07C 229/56 (2006.01) C07C 229/64 (2006.01) C07C 229/66 (2006.01) C07C 233/54 (2006.01) C07C 271/28 (2006.01) C07D 209/04 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 235/02 (2006.01) C07D 235/12 (2006.01) C07D 235/16 (2006.01) C07D 265/30 (2006.01) C07D 295

Patent

CA 2332806

A compound which consists of a proactive alkylating moiety containing an electron-withdrawing group, a bioreductive moiety containing at least two double bonds, and a linker joining the proactive alkylating moiety and the bioreductive moiety.

L'invention concerne un composé constitué d'une fraction alkylante proactive contenant un groupe attracteur d'électrons. L'invention concerne également une fraction bioréductrice contenant au moins deux doubles liaisons. L'invention concerne enfin une séquence de liaison reliant ladite fraction alkylante proactive et la fraction bioréductrice.

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