Bioresorbable compositions for implantable prostheses

C - Chemistry – Metallurgy – 08 – G

Patent

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Details

C08G 65/02 (2006.01) A61K 9/107 (2006.01) A61L 27/34 (2006.01) A61L 27/52 (2006.01) A61L 27/58 (2006.01) C08G 63/06 (2006.01) C08G 63/08 (2006.01) C08J 3/24 (2006.01) C08J 3/28 (2006.01)

Patent

CA 2303807

Cross-linked compositions formed from a water-insoluble copolymer are disclosed. These compositions are copolymers having a bioresorbable region, a hydrophilic region and at least two crosslinkable functional groups per polymer chain. These compositions are able to form hydrogels in aqueous environments when cross-linked. These hydrogels are good sealants for implantable prostheses when in contact with an aqueous environment. In addition, such hydrogels can be used as delivery vehicles for therapeutic agents.

La présente invention concerne des compositions réticulées obtenues à partir d'un copolymère insoluble dans l'eau. Ces compositions sont des copolymères ayant une région biorésorbable, une région hydrophile et au moins deux groupes fonctionnels réticulables par chaîne polymère. Par ailleurs, ces compositions peuvent former des hydrogels dans des environnement aqueux lorsqu'elles sont réticulées. Ces hydrogels constituent de bons agents de scellement pour les prothèses implantables lorsqu'ils sont en contact avec un environnement aqueux. De plus, ces hydrogels peuvent être utilisés comme vecteurs pour des agents thérapeutiques.

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