Bioresponsive polymers

Details Bioresponsive polymers Bioresponsive polymers

C - Chemistry, Metallurgy

08

G

C08G 69/00 (2006.01) A61K 47/48 (2006.01) A61L 27/14 (2006.01) A61L 27/54 (2006.01) A61L 27/58 (2006.01) A61L 29/04 (2006.01) A61L 29/14 (2006.01) A61L 29/16 (2006.01) A61L 31/04 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01) A61P 29/00 (2006.01) C07K 17/00 (2006.01) C08G 83/00 (2006.01) C08L 101/16 (2006.01) C07K 7/06 (2006.01) C12N 9/48 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2656112

The invention features biodegradable polymers for the delivery of biologically active agents. The polymers include at least one biologically active agent covalently attached via a polyamide linker susceptible to selective hydrolysis by peptidase enzymes. Hydrolysis of the polyamide linker releases the biologically active agent in vivo.

L'invention concerne des polymères biodégradables destinés à l'administration d'agents biologiquement actifs. Les polymères comprennent au moins un agent biologiquement actif lié de façon covalente par l'intermédiaire d'une liaison polyamide sensible à une hydrolyse sélective par des enzymes peptidases. L'hydrolyse de la liaison polyamide libère l'agent biologiquement actif in vivo.

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