Biosensor electrode mediators for regeneration of cofactors

Details Biosensor electrode mediators for regeneration of cofactors Biosensor electrode mediators for regeneration of cofactors

C - Chemistry, Metallurgy

12

Q

C12Q 1/32 (2006.01) C12Q 1/00 (2006.01) G01N 27/30 (2006.01) G01N 27/327 (2006.01)

Patent

CA 2305800

The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.

La présente invention est basée sur la découverte de composés médiateurs de NAD?+¿ et de NADP?+¿ ne se liant pas de manière irréversible à des groupes thiol dans les sites actifs d'enzymes déshydrogénases intracellulaires. Ces composés médiateurs évitent un mode commun d'inhibition d'enzyme. Les médiateurs peuvent par conséquent augmenter la stabilité et la fiabilité de la réponse électrique dans des électrodes ampèremétrique construites à partir d'enzymes dépendantes de NAD ou de NADP.

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