Biosensor electrode mediators for regeneration of cofactors

Details Biosensor electrode mediators for regeneration of cofactors Biosensor electrode mediators for regeneration of cofactors

G - Physics

01

N

G01N 27/403 (2006.01) G01N 27/327 (2006.01) G01N 27/416 (2006.01) G01N 33/487 (2006.01) G01N 33/53 (2006.01) G01N 33/66 (2006.01)

Patent

CA 2667767

The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP- dependent enzymes.

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