Biosensor using whispering gallery modes in microspheres

Details Biosensor using whispering gallery modes in microspheres Biosensor using whispering gallery modes in microspheres

G - Physics

01

N

G01N 21/25 (2006.01) G01N 21/63 (2006.01)

Patent

CA 2567786

A biosensor for detecting the presence of a target analyte is disclosed. The biosensor is formed from microspheroidal particles which have had a binding partner for the target analyte immobilized on their surfaces. The binding partners may be nucleotides; peptides, proteins, enzymes, antibodies and so on. When the analyte binds to its partner, the whispering gallery mode (WGM) profiles of the microspheroidal particles change such that the profile peaks undergo a red- or blue-shift. The immobilised binding partners may include fluorophores and the like so that they emit fluorescence, phosphorescence, incandescence and the like. These fluorophores may take the form of a nanocrystal or quantum dot.

L'invention concerne un biodétecteur destiné à détecter la présence d'un analyte cible. Le biodétecteur est composé de particules microsphéroïdales qui présentent un partenaire de liaison pour l'analyte cible immobilisé sur leurs surfaces. Les partenaires de liaison peuvent être des nucléotides, des peptides, des protéines, des enzymes, des anticorps et analogues. Lorsque l'analyte est lié à son partenaire, les profils en mode de voûte acoustique (WGM) des particules microsphéroïdales se transforme, de manière à ce que les pics de profils soient soumis à un déplacement hypsochrome ou bathochrome. Les partenaires de liaison immobilisés peuvent comprendre des agents fluorophores et analogues, de manière à émettre de la fluorescence, de la phosphorescence, de l'incandescence, et analogues. Lesdits agents fluorophores peuvent se présenter sous la forme de nanocristal ou de point quantique.

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