C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/78 (2006.01) A61L 27/00 (2006.01) A61L 27/48 (2006.01) C07K 14/75 (2006.01) C07K 17/02 (2006.01) C08B 15/00 (2006.01) C08B 37/00 (2006.01) C08G 81/00 (2006.01) C08H 1/06 (2006.01)
Patent
CA 2164262
Biomaterials like collagen can be designed for use as scaffolds for connective tissue reconstruction. It is known that proteins conjugated with PEGs exhibit a decrease in their biodegradation rate and their immunogenicity. Different concentrations and molecular weights of PEGs (PEG-750 and PEG-5000) were conjugated by chemical or irradiation means to collagen materials (films or sponges) which were then investigated by physicochemical assays, collagenase assay, fibroblast cell culture and subcutaneous implantation. PEG-conjugation delayed the degradation by collagenase and preserved a normal fibroblasts morphology and confluency in culture. In vivo, the porous structure of non-modified sponges was collapsed by day 15 with few observable fibroblasts between the collagen fibers. In PEG-modified collagen sponges, the porous structure remained stable for at least 30 days. Cell infiltration was particularly enhanced in PEG-750-conjugated collagen sponges. In conclusion, PEGs conjugated onto collagen sponges stabilize the porous structure without deactivating the biological properties of collagen. These porous composite materials could advantageously function as a scaffold to organize tissue ingrowth. Therefore, the present invention relates to a porous biomaterial whose porosity is stabilized by conjugation to PEG-derivatives. Biopolymers other than collagen may be used in the making of such composite materials.
Doillon Charles J.
Gaudreault Rene C.
Pietrucha Krystina
Doillon Charles J.
Gaudreault Rene C.
Goudreau Gage Dubuc
Pietrucha Krystina
Universite Laval
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