Biosynthesis of hyaluronic acid

C - Chemistry – Metallurgy – 12 – P

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C12P 19/04 (2006.01) C12P 19/26 (2006.01)

Patent

CA 2011845

BIOSYNTHESIS OF HYALURONIC ACID ABSTRACT OF THE DISCLOSURE Improved overall yields of hyaluronic acid are obtained by controlling the oxygen available for metabolism by a hyaluronic acid producing microorganism. Relatively high oxygen concentrations are made available during the initial exponential growth phase of the cultivated microorganism, until a predetermined growth has been reached. At this time, the available oxygen is limited to stimulate a disproportionately larger production of the desired hyaluronic acid.

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