Biosynthesis of polyketide synthase substrates

Details Biosynthesis of polyketide synthase substrates Biosynthesis of polyketide synthase substrates

C - Chemistry, Metallurgy

12

P

C12P 11/00 (2006.01) C12N 1/21 (2006.01) C12P 19/62 (2006.01)

Patent

CA 2383965

The use of enzymes which catalyze the production of starter and extender units for polyketides is described. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli. This achievement permits a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

La présente invention concerne l'utilisation d'enzymes catalysant la production d'unités de démarrage et d'extension pour polykétides. Ces enzymes peuvent être utilisées afin d'améliorer le rendement de polykétides qui sont produits naturellement ou de polykétides qui sont conçus de façon rationnelle. Par l'utilisation de ces techniques, la synthèse d'un polykétide complet s'est concrétisée en E.coli. Cette concrétisation permet à un organisme hôte présentant des caractéristiques souhaitées d'être utilisé dans la production de tels polykétides et d'évaluer les résultats de remaniement génétique.

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