Biosynthesis of unnatural cephalosporins

Details Biosynthesis of unnatural cephalosporins Biosynthesis of unnatural cephalosporins

C - Chemistry, Metallurgy

12

P

195/123, 195/81,

C12P 35/00 (2006.01) C12N 11/08 (2006.01)

Patent

CA 1206901

ABSTRACT OF THE DISCLOSURE A process for converting a peptide precursor of the ACV type,in which the valine moiety may be replaced by any readily available amino acid,to an unnatural cephalosporin of the type Image where R1 is H, lower alkyl or functionalized carboxylic group and R2 is H or lower alkyl, in which the precursor is reacted with cyclase, epimerase and a ring expansion enzyme isolated from a cell-free extract of a prokaryotic organism such as Streptomyces clavuligerus. The three enzymes may be immobllized on a suitable support medium and the conversion may be carried out in a continuous mode.

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