Biosynthesis of unnatural cephalosporins

Details Biosynthesis of unnatural cephalosporins Biosynthesis of unnatural cephalosporins

C - Chemistry, Metallurgy

12

P

195/123, 195/37,

C12P 35/00 (2006.01) C07K 5/078 (2006.01) C12N 9/00 (2006.01) C12N 9/90 (2006.01) C12N 11/18 (2006.01) C12P 35/06 (2006.01) C12P 37/00 (2006.01)

Patent

CA 1204070

ABSTRACT OF THE DISCLOSURE A process for converting a peptide precursor of the ACV type, in which the valine moiety may be replaced by any readily available amino acid,to an unnatural cephalosporin of the type Image where Rl is H, lower alkyl or functionalizied carboxylic group and R2 is H or lower alkyl,in which the precursor is reacted with cyclase, epimerase and a ring expansion enzyme isolated from a cell-free extract of a prokaryotic organism such as Streptomyces clavuligerus. The three enzymes may be immobilized on a suitable support medium and the conversion may be carried out in a continuous mode.

432280

Affiliated with

Also associated with

Rating

Biosynthesis of unnatural cephalosporins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biosynthesis of unnatural cephalosporins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biosynthesis of unnatural cephalosporins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1340516