Biosynthetic binding protein for cancer marker

Details Biosynthetic binding protein for cancer marker Biosynthetic binding protein for cancer marker

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) C07K 16/22 (2006.01) C07K 16/30 (2006.01) C07K 16/32 (2006.01) C07K 16/46 (2006.01) C12N 15/62 (2006.01) A61K 43/00 (1990.01)

Patent

CA 2129663

Disclosed is a single-chain Fv (sFv) polypeptide defining a binding site which exhibits the immunological binding propert- ies of an immunoglobulin molecule which binds c-erbB-2 or a c-erbB-2-related tumor antigen, the sFv includes at least two poly- peptide domains connected by a polypeptide linker spanning the distance between the C-terminus of one domain and the N- terminus of the other, the amino acid sequence of each of the polypeptide domains includes a set of complementarity determining regions (CDRs) interposed between a set of framework regions (FRs), the CDRs conferring immunological binding to the c-erbB- 2 or c-erbB-2-related tumor antigen.

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