Biosynthetic binding protein for cancer marker

Details Biosynthetic binding protein for cancer marker Biosynthetic binding protein for cancer marker

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/66 (2006.01)

Patent

CA 2372813

Disclosed is a single-chain Fv (sFv) polypeptide defining a binding site which exhibits the immunological binding properties of an immunoglobulin molecule which binds c-erbB-2 or a c-erbB-2-related tumor antigen, the sFv includes at least two polypeptide domains connected by a polypeptide linker spanning the distance between the C-terminus of one domain and the N-terminus of the other, the amino acid sequence of each of the polypeptide domains includes a set of complementarity determining regions (CDRs) interposed between a set of framework regions (FRs), the CDRs conferring immunological binding to the c-erbB-2 or c-erbB-2-related tumor antigen.

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