A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/38 (2006.01) A61L 27/54 (2006.01) A61L 27/58 (2006.01)
Patent
CA 2713118
An isolated, acellular biosynthetic cartilaginous matrix substantially devoid of synthetic biodegradable scaffold structure is provided. Through a method with the steps of a) contacting in vitro a population of chondrogenic cells with a synthetic biodegradable scaffold; b) culturing in vitro for a period of time said chondrogenic cells within said synthetic biodegradable scaffold so that the chondrogenic cells produce a biosynthetic cartilaginous matrix; c) substantially removing any antigen derived from said chondrogenic cells a matrix suitable of implantation into a living individual mammal, such as a human being is obtained.
L'invention porte sur une matrice cartilagineuse biosynthétique acellulaire, isolée, sensiblement exempte de structure d'échafaudage biodégradable synthétique. En conduisant un procédé avec les étapes consistant à a) mettre en contact in vitro une population de cellules chondrogéniques avec un échafaudage biodégradable synthétique ; b) cultiver in vitro pendant une période de temps lesdites cellules chondrogéniques à l'intérieur dudit échafaudage biodégradable synthétique de telle sorte que les cellules chondrogéniques produisent une matrice cartilagineuse biosynthétique ; c) retirer sensiblement tout antigène issu desdites cellules chondrogéniques, on obtient une matrice appropriée d'implantation dans un mammifère individuel vivant, tel qu'un être humain.
Clausen Christian
Everland Hanne
Samuelsen Peter
Vange Jakob
Coloplast A/s
Interface Biotech A/s
Ridout & Maybee Llp
LandOfFree
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