Biosynthetic constructs of tgf-beta

Details Biosynthetic constructs of tgf-beta Biosynthetic constructs of tgf-beta

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 1/107 (2006.01) C07K 14/495 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2070393

-33- ABSTRACT OF THE DISCLOSURE Disclosed are constructs of truncated transforming growth factor-beta (TGF-.beta.) produced by expression of recombinant DNA in a prokaryotic host cell. These constructs include at least one polypeptide chain of fewer than about 112 amino acides and fewer than 9 cysteine residues. The sequence of amino acids in these constructs is sufficiently duplicative of the sequence of native transforming growth factor-beta such that it is capable of inducing an anti-proliferative effect on mammalian epithelial cells in vitro. Also disclosed are methods of producing analogs of TGF-.beta. using recombinant DNA technology, and methods of using such analogs.

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