Biosynthetic gene muri from streptococcus pneumoniae

Details Biosynthetic gene muri from streptococcus pneumoniae Biosynthetic gene muri from streptococcus pneumoniae

C - Chemistry, Metallurgy

12

N

C12N 15/61 (2006.01) C12N 9/90 (2006.01) C12N 15/10 (2006.01) C12Q 1/533 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2273844

The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murI of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurI enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.

L'invention concerne des composés nucléotidiques isolés, codant le gène murI souche biosynthétique et peptidique de Streptococcus pneumoniae. L'invention concerne également des vecteurs et des cellules hôtes hétérologues et transformées, destinés à exprimer le produit enzymatique MurI, de même qu'un procédé d'identification de composés inhibant la biosynthèse du peptide souche.

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