Biosynthetic oncolytic molecules and uses therefor

Details Biosynthetic oncolytic molecules and uses therefor Biosynthetic oncolytic molecules and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/19 (2006.01) A61P 35/00 (2006.01) C07K 14/52 (2006.01) C12N 15/19 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2411346

Novel biosynthetic oncolytic molecules are provided. The biosynthetic oncolytic molecules include functional domains derived from osteopontin. Preferred biosynthetic oncolytic molecules include an apoptotic domain derived from osteopontin. The oncolytic molecules of the present invention are capable of promoting cellular apoptosis. Accordingly, therapeutic uses are disclosed which feature the biosynthetic oncolytic molecules of the present invention.

L'invention concerne de nouvelles molécules oncolytiques biosynthétiques. Ces molécules oncolytiques biosynthétiques comprennent des domaines fonctionnels dérivés de l'ostéopontine. De préférence, ces molécules oncolytiques biosynthétiques comprennent un domaine apoptotique dérivé de l'ostéopontine. Les molécules oncolytiques de la présente invention peuvent favoriser l'apoptose cellulaire. En conséquence, l'invention concerne également des usages thérapeutiques faisant appel aux molécules oncolytiques biosynthétiques de la présente invention.

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