Biosynthetic process for the preparation of lantibiotics

Details Biosynthetic process for the preparation of lantibiotics Biosynthetic process for the preparation of lantibiotics

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 1/113 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/245 (2006.01) C07K 14/31 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 9/00 (2006.01) C12N 15/52 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2081704

A bacterial host is described which is transformed by a plasmid coding for a polypeptide precursor wherein the host comprises a multi-enzyme complex capable of reacting with the expressed polypeptide precursor to produce a polypeptide comprising at least one dehydroamino acid and/or at least one lanthione bridge. A process for producing a polypeptide comprising at least one dehydroamino acid and/or at least one lanthione bridge, such as gallidermin, is also described. A plasmid capable of transforming a bacterial host is additionally described. Also disclosed are recombinant DNA molecules which specify Epi B, Epi C, Epi D, Epi P and Epi Q, enzymes which are involved in the biosynthesis of lantibiotic epidermin.

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