C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/18 (2006.01) C12P 7/42 (2006.01) C12P 17/06 (2006.01)
Patent
CA 2053000
Biosynthetic production of 6(R)-[2-(8(S)-hydroxy-2(S),6(R)-dimethyl-1,2,6,7,8,8a- (R)-hexahydronaphthyl)ethyl]-4(R)-hydroxy-3,4,5,6- tetrahydro-2H-pyran-2-one triol acid is obtained by enzymatic hydrolysis of lovastatin acid or a salt thereof, by treating it with Clonostachys compactiuscula or mutants thereof, or a hydrolase derived therefrom. The triol acid may be converted in a straightforward manner to its lactone form; and both are inhibitors of HMG-CoA reductase and thus useful as antihypercholesterolemic agents, and may also serve as intermediates for preparation of other HMG-CoA reductase inhibitors.
Conder Michael J.
Cover William H.
Dabora Rebecca L.
Stieber Robert W.
Tehlewitz Bogdan
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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