Biotherapeutic cell-coated microspheres

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 11/02 (2006.01) A61K 8/11 (2006.01) A61K 8/98 (2006.01) A61K 9/16 (2006.01) A61K 35/36 (2006.01) A61L 27/60 (2006.01) A61Q 19/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2135999

A living skin replacement for the treatment of partial-and full-thickness skin injuries, such as burns and other wounds, consists of a slurry of cell-coated microspheres which can be applied to the skin injury in much the same manner as a paste or salve. The skin implant can accommodate contour variations across the often extensive area of a skin injury and does not require the use of stapling, suturing, or other attachment methods. The microspheres can be formed of a variety of materials that are bio-compatible and resorbable in vivo.

Un substitut de peau vivante utilisé dans le traitement des lésions de la peau profondes ou partielles telles que les brûlures ou autres lésions, consiste en une boue de microsphères recouvertes de cellules qui peut être appliquée sur les lésions cutanées de la même manière qu'une pâte ou une pommade. L'implant dermique peut s'adapter aux variations de contour rencontrées dans les lésions cutanées de surface souvent importantes et il ne nécessite pas l'utilisation d'agrafes, de points de suture ou autres procédés de fixation. Les microsphères peuvent être composées de différents matériaux biocompatibles et résorbables in vivo.

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