A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2209767
Cytotoxic biotherapeutic agents effective for treating certain types of cancer in humans are provided which comprise the TP-3 murine monoclonal antibody chemically conjugated to pokeweed antiviral protein (PAP). The invention further provides a method which utilizes the disclosed cytotoxic biotherapeutic agents to systemically treat cancer patients. With slight modifications the method of the present invention should be generally applicable to preparation and use of other cytotoxic biotherapeutic agents using chemical or recombinant derivatives of the TP-3 or TP-1 antibodies or PAP toxin. The invention is applicable to cancer patients who express the p80 antigen recognized by the TP-1/TP-3 antibodies either on the surface of their tumor cells or on the tumor blood vessels.
L'invention concerne des agents biothérapeutiques cytotoxiques permettant de traiter certains types de cancer chez l'homme et comprenant l'anticorps monoclonal de murine de TP-3 conjugué chimiquement à la protéine antivirale du phytolaque (PAP). L'invention concerne, de plus, un procédé utilisant ces agents dans le traitement systémique de patients atteints du cancer. On devrait pouvoir appliquer ce procédé, avec de légères modifications, à la préparation et à l'utilisation d'autres agents biothérapeutiques cytotoxiques au moyen de dérivés chimiques ou recombinants des anticorps de TP-3 ou de TP-1 ou de la toxine de PAP. L'invention peut s'appliquer à des patients qui expriment l'antigène de p80 reconnu par les anticorps de TP-1/TP-3 soit sur la surface de leurs cellules cancéreuses, soit sur les vaisseaux sanguins de la tumeur.
Anderson Peter M.
Uckun Fatih M.
Robic
The Regents Of The University Of Minnesota
LandOfFree
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