Biotinderivate

Details Biotinderivate Biotinderivate

C - Chemistry, Metallurgy

07

K

C07K 7/64 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/12 (2006.01) C07K 1/22 (2006.01) C07K 5/10 (2006.01) C07K 7/04 (2006.01) C07K 14/75 (2006.01) C07K 14/78 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2185394

Biotin compounds of the formula I (see formula I) is which Q is absent, -NH-(CH2)n-CO or -NH-(CH2)n-NH- and R1 is X-Arg-Gly-Asp-Y, A-Cys(R2)-B-U or cyclo-(Arg-Gly-Asp-Z), where Z is bonded in the side chain to Q or, if Q is absent, to biotin, and A, B, U, X, Y, Z and n have the meanings stated is Claim 1, and their salts can be used as integrin inhibitors, in particular for the prophylaxis and treatment of disorders of the circulation, for thrombosis, myocardial infarct, coronary heart diseases, arteriosclerosis, angiogenic disorders and is tumour therapy.

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