C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) G01N 33/532 (2006.01) G01N 33/543 (2006.01) G01N 33/58 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2142867
A unique class of chemiluminescent labels containing biotin substitution that are suitable for chemiluminescent assays using inter alia a streptavidin and/or avidin conjugate. The chemiluminescent labels of the invention have the ability to bind to streptavidin and/or avidin per se or to streptavidin and/or avidin conjugated with an analyte. Label structures are disclosed that have hydrolytic stability to meet the most demanding commercial assay conditions. The chemiluminescent label compounds contain a biotin substituent that forms a streptavidin or avidin complex, having the formula: (see above formula) in which R1 is a divalent organic group; and R2 is an optional substituent of the biotin and when present it is a divalent moiety containing at least 1 carbon atom; and R o is a heterocyclic structure directly bonded to the biotin or substituted biotin, that has the capacity of exhibiting chemiluminescence when reacted with hydrogen peroxide in the presence of a base. The invention encompasses conjugates containing associated versions of the labeling compounds, assays and kits for performing such assay utilizing the conjugates.
Nichols Institute Diagnostics
Sim & Mcburney
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