Biotinylated-chemokine antibody complexes

Details Biotinylated-chemokine antibody complexes Biotinylated-chemokine antibody complexes

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2371849

Biotinylated pharmacologically active agents and complexes containing same are disclosed. In particular, biotinylated-chemokines are described. The complexes further include an anti-biotin antibody that selectively binds to biotin. The complex can be dissociated by contact with free biotin. The complexes are particularly useful for enhancing an immune response to tumor cells and virus- infected cells, in vivo or in vitro.

L'invention concerne des agents actifs pharmacologiquement biotinylés, ainsi que des complexes renfermant lesdits agents. L'invention concerne, en particulier, des chimiokines biotinylées. Les complexes précités comprennent également un anticorps anti-biotine liant sélectivement la biotine. Ces complexes, qui peuvent se dissocier au contact de biotine libre, sont particulièrement utiles pour accroître la réponse immunitaire aux cellules tumorales et aux cellules infectées par virus, in vivo ou in vitro.

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