Biotinylated hexadecasaccharides, preparation and use thereof

Details Biotinylated hexadecasaccharides, preparation and use thereof Biotinylated hexadecasaccharides, preparation and use thereof

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01) A61K 31/715 (2006.01)

Patent

CA 2577258

The invention concerns novel biotinylated hexadecasaccharides of general formula (I) wherein: Biot is a biotin derivative; R, R1 and R2, represent independently of one another a C1-C6 alkoxy or and -OSO3; R3 represents a C1-C6 alkoxy or an -OSO3, or R3 constitutes a -O-CH2- bridge; Pe represents a saccharide concatenation; as well as their pharmaceutically acceptable salts, and their use as medicines.

La présente invention concerne de nouveaux hexadécasaccharides biotinylés de formule générale (I) dans laquelle : - Biot est un dérivé de biotine; - R1 R1 et R2, représentent indépendamment l'un de l'autre un (C1-C6)alcoxy ou un - OSO3 -, - R3 représente un (C1-C6)alcoxy ou un -OSO3 -, ou bien R3 constitue un pont -O-CH2- ; - Pe représente un enchaînement saccharidique ; ainsi que leurs sels pharmaceutiquement acceptables, et leur utilisation comme médicaments.

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