Biphasic lipid-vesicle composition and method for treating...

Details Biphasic lipid-vesicle composition and method for treating... Biphasic lipid-vesicle composition and method for treating...

A - Human Necessities

61

K

A61K 38/21 (2006.01) A61K 9/06 (2006.01) A61K 9/107 (2006.01) A61K 9/127 (2006.01) A61K 31/198 (2006.01)

Patent

CA 2681565

A biphasic lipid vesicle composition for treating cervical displasia by intravaginal delivery. The composition includes a suspension of lipid-bilayer vesicles having entrapped therein, an oil-in-water emulsion, human interferon alpha-2b and L-methionine, the composition having an interferon alpha-2b specific activity of between about 1-10 MIU (million international units) per gram composition, and between 0.01 to 0.5 weight percent L-methionine. In the treatment method, the composition is administered at a dose of between about 1- 20 MIU interferon alpha-2b, and this dose is administered at least 3 days/week, for a period of at least 4 weeks.

L'invention concerne une composition de vésicules lipidiques biphasiques pour traiter une dysplasie du col de l'utérus par administration intravaginale. La composition comprend une suspension de vésicules bicouches lipidiques dans lesquelles sont piégés une émulsion huile-dans-eau, l'interféron alpha-2b humain et la L-méthionine, la composition ayant une activité spécifique de l'interféron alpha-2b d'entre environ 1-10 MIU (million d'unités internationales) par gramme de composition, et entre 0,01 et 0,5 pour cent en poids de L-méthionine. Dans le procédé de traitement, la composition est administrée à une dose d'entre environ 1-20 MIU d'interféron alpha-2b, et cette dose est administrée au moins 3 jours/semaine, pendant une période d'au moins 4 semaines.

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