A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/277 (2006.01) A61K 31/085 (2006.01) A61P 5/28 (2006.01) A61P 13/08 (2006.01) A61P 17/10 (2006.01) C07C 255/50 (2006.01) C07C 255/51 (2006.01) C07C 255/54 (2006.01) C07C 255/57 (2006.01) C07C 255/58 (2006.01) C07D 295/192 (2006.01)
Patent
CA 2474171
Biphenyl derivatives are disclosed for use in the treatment of androgen- dependent diseases such as prostate cancer, benign prostatic hyperplasia, precicious puberty, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and premature male baldness. For example, some preferred compounds having the structure (formula I): are formulated together with pharmaceutically acceptable diluent or carrier for topical use in the treatment of androgen-dependent prostate cancer.
Cette invention concerne des dérivés biphényle s'utilisant dans le traitement de maladies androgène-dépendantes telles que le cancer de la prostate, l'hyperplasie prostatique bénigne, la puberté précoce, le syndrome de Stein-Leventhal, l'acné, l'hirsutisme, la séborrhée, l'alopécie androgénique et la calvitie prématurée chez l'homme. Par exemple, certains composés préférés, représentée par la structure (formule I): sont préparés avec un diluant ou un excipient acceptables au plan pharmaceutique pour application topique dans le traitement du cancer androgène-dépendant de la prostate.
Labrie Fernand
Luu-The Van
Singh Shankar Mohan
Endorecherche Inc.
Marks & Clerk
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