C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/21 (2006.01) A61K 31/18 (2006.01) A61P 17/06 (2006.01) A61P 19/00 (2006.01) A61P 19/02 (2006.01) A61P 19/08 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2681320
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl sulfonamides and related compounds (collectively referred to herein as "BPSAAA compounds"), as described herein, and including, for example, biphenyl-4-sulfonic acid (hydroxyalkyl-phenyl)-amides and related compounds. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment and/or prevention, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of, inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activation in rheumatoid arthritis, osteoporosis, cancer associated bone disease, Paget's disease and the like.
La présente invention concerne de manière générale le domaine des composés thérapeutiques et plus précisément certains aryle sulfonamides et des composés apparentés (nommés collectivement dans le présent document <= composés BPSAAA >=) tels que décrits dans le présent document. Ces composés comprennent, par exemple, les amides de l'acide biphényl-4-sulfonique (hydroxyalkyl-phényl) et des composés apparentés. La présente invention concerne également des compositions pharmaceutiques qui comprennent de tels composés, ainsi que l'utilisation de tels composés et de telles compositions, à la fois in vitro et in vivo, pour le traitement et/ou la prévention, par exemple, de l'inflammation et/ou de la destruction des articulations et/ou de la perte osseuse; de troubles induits par une activation excessive et/ou inappropriée et/ou prolongée du système immunitaire; de troubles inflammatoires et autoimmuns, par exemple la polyarthrite rhumatoïde, le psoriasis, la polyarthrite psoriasique, la maladie pulmonaire obstructive chronique (MPOC), l'athérosclérose, la maladie intestinale inflammatoire, la spondylite ankylosante et des troubles analogues; de troubles associés avec la perte osseuse, tels que la perte osseuse associée avec l'activation excessive des ostéoclastes dans la polyarthrite rhumatoïde, l'ostéoporose, les maladies osseuses associées à un cancer, la maladie de Paget et des troubles analogues.
Greig Iain Robert
Ralston Stuart Hamilton
Van 't Hof Robert Jurgen
Kirby Eades Gale Baker
The University Court Of The University Of Aberdeen
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