C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/12 (2006.01) A61K 31/4015 (2006.01) A61P 3/10 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 403/10 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 487/08 (2006.01) C07D 491/08 (2006.01) C07D 491/10 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2649741
The present invention discloses novel compounds of Formula I: possessing 11 ß-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11 ß -HSD type 1 activity.
La présente invention concerne de nouveaux composés de formule I : possédant une activité antagoniste de la 11.beta.-HSD de type 1, ainsi que des procédés servant à préparer de tels composés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques comprenant des composés de formule I, ainsi que des procédés d'utilisation des composés et des compositions pour traiter le diabète, l'hyperglycémie, l'obésité, l'hypertension, l'hyperlipidémie, un syndrome métabolique, des troubles cognitifs et d'autres affections associées à l'activité de la 11.beta.-HSD de type 1.
Aicher Thomas Daniel
Chen Zhaogen
Hinklin Ronald Jay
Hite Gary Alan
Krasutsky Alexei Pavlovych
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
Biphenyl amide lactam derivatives as inhibitors of 11-... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biphenyl amide lactam derivatives as inhibitors of 11-..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biphenyl amide lactam derivatives as inhibitors of 11-... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1537784