Biphenyl and biphenyl-analogous compounds as integrin...

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

IPC codes

C07C 311/19 (2006.01) A61K 31/18 (2006.01) A61K 31/4184 (2006.01) A61K 31/44 (2006.01) A61P 19/10 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01) C07C 271/22 (2006.01) C07C 275/42 (2006.01) C07C 311/06 (2006.01) C07C 311/10 (2006.01) C07C 311/14 (2006.01) C07C 311/37 (2006.01) C07C 311/46 (2006.01) C07C 311/47 (2006.01) C07C 335/20 (2006.01) C07D 207/22 (2006.01) C07D 213/40 (2006.01) C07D 213/55 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01) C07D 213/82 (2006.01) C07D 231/18 (2006.01) C07D 233/5

Type

Patent

Patent number

CA 2355161

Description

The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of cancer, arteriosclerosis, restenosis, osteolytic disorders such as osteoporosis and ophthalmic diseases. The compounds according to the invention have formula (1) wherein R1, R2, U, V, A, B, W, R3, C and R4 have the meaning as defined in the claims.

L'invention concerne des composés de biphényle et d'analogues de biphényle, leur préparation et leur utilisation en tant que compositions pharmaceutiques, en qualité d'antagonistes d'intégrines, et notamment en vue de produire des compositions pharmaceutiques destinées au traitement et à la prophylaxie du cancer, de l'artériosclérose, de la resténose, de troubles ostéolytiques tels que l'ostéoporose et les maladies ophtalmiques. Selon l'invention, la formule des composés est (1), où R?1¿, R?2¿, U, V, A, B, W, R?3¿, C et R?4¿ sont tels que définis dans les revendications.

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