(biphenyl) carboxylic acids and derivatives thereof

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 59/68 (2006.01) A61K 31/192 (2006.01) A61P 25/28 (2006.01) C07C 59/72 (2006.01) C07C 235/34 (2006.01) C07C 311/17 (2006.01) C07C 317/22 (2006.01) C07D 261/08 (2006.01) C07D 295/18 (2006.01) C07D 295/22 (2006.01) C07D 309/06 (2006.01)

Patent

CA 2584664

The present invention relates to compounds having the general formula (I) with the definitions of A, X, R1-R6 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of .gamma.- secretase activity.

La présente invention concerne des composés ayant la formule générale (I) avec les définitions de A, X, R1-R6 données ci-après, et/ou un sel ou un ester de ces composés. L'invention concerne également l'utilisation de ces composés pour le traitement de la maladie d'Alzheimer et leur utilisation pour la modulation de l'activité de ?-secrétase.

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