Biphenyl compounds useful as muscarinic receptor antagonists

Details Biphenyl compounds useful as muscarinic receptor antagonists Biphenyl compounds useful as muscarinic receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 211/62 (2006.01)

Patent

CA 2557479

This invention provides compounds of formula (I): wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula (I) are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Cette invention concerne des composés représentés par la formule (I): dans laquelle a, b, c, d, m, n, p, s, t, W, Ar?1¿, R?1¿, R?2¿, R?3¿, R?4¿, R?6¿, R?7¿ et R?8¿ sont comme définis dans le descriptif. Les composés de formule (I) sont des antagonistes du récepteur muscarinique. L'invention concerne également des compositions pharmaceutiques contenant de tels composés, des procédés et des intermédiaires intervenant dans la fabrication de tels composés et des méthodes d'utilisation de ces composés pour le traitement de troubles pulmonaires.

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